First Human Ebola Vaccine Trial Produces Positive Results

Source: NBC News
The first test of an Ebola vaccine in people shows it’s safe and appears to be working as designed, doctors reported Wednesday.
A look at the first 20 people injected with the vaccine, which has been shown to protect monkeys from Ebola, shows no dangerous side effects. And it seems to be producing an immune response that would be expected to protect them from infection.
“This response is very comparable to the level of the response that actually protected the animals,” said Dr. Tony Fauci, head of the National Institute for Allergy and Infectious Diseases (NIAID), which helped develop and test the vaccine.

The hope is to be able to make enough vaccine to at least protect health care workers fighting the epidemic…Doctors, nurses and other health care workers who treat actual Ebola patients are at especially high risk. The World Health Organization says 588 health care workers have been infected with Ebola and 337 have died of it.

Ebola is raging through Sierra Leone, Liberia and Guinea. It’s infected more than 15,000 people and killed 5,000 of them…
There’s no ethical way to vaccinate people and then expose them to Ebola on purpose, of course, so the trial is designed to see if the vaccine is safe and if the immune system responds in a way that would be expected to protect them. It did, the NIAID researchers report in the New England Journal of Medicine…
WHO officials hope to be able to use at least one of the vaccines to start immunizing health care workers by January. “Based on these positive results from the first human trial of this candidate vaccine, we are continuing our accelerated plan for larger trials to determine if the vaccine is efficacious in preventing Ebola infection,” Dr. Fauci said.
The worst side-effect was a brief fever in two volunteers who got a high dose of the vaccine…Dr. Fauci told NBC News…”The good news is that the fever was very transient. It lasted less than 24 hours.”
The same vaccine is being tested at the University of Maryland, in Britain and in Mali. A different Ebola vaccine, made using a different virus, is being tested at NIAID, part of the National Institutes of Health, and at the nearby Walter Reed Army Institute of Research.

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